Skin cancer vaccine hope

From the Sun-Hearld

CANCER expert Prof Ian Frazer is on the verge of a major breakthrough in skin cancer – he hopes to develop a vaccine within a year.

The former Australian of the Year and creator of the world’s first cervical cancer vaccine, Gardasil, has developed a world-first strategy to combat the insidious disease that affects two out of three Australians.

“In my lifetime we should be able to remove the threat of skin cancer from the next generation,” the 57-year-old immunology professor said.

“The smoking gun evidence is there is a virus or viruses that cause it.”

Prof Frazer believes people can “catch” cancer from a virus.

He proved his theory by identifying the human papilloma virus (HPV) as the cause of cervical cancer and then developing a vaccine against the virus to rid the female population of the cancer.

Now he is using a similar tactic to try to combat skin cancer, including malignant melanomas.

“This group of cancers caused by virus infection present a great opportunity because the idea of vaccinating to prevent a cancer is enormously appealing,” he said.

Prof Frazer said the problem was two-fold.

“Genetics and variations in people’s immune systems may expose some people to greater risk of skin cancer after sun exposure,” he said.

“If you take away the body’s defence systems, skin cancer becomes more common.”

His theory is that some viruses – particularly the wart virus or HPV – are embedded in the layers of the skin, which then pose a skin cancer risk for people with damaged immune systems.

“The technology now exists for me to test my theory,” Prof Frazer said.

“It is very powerful but also very expensive.

“Using this tool, we will go hunting for the fingerprints of the virus or viruses present.”

Prof Frazer’s team will input all the sequenced genetic information on skin cancer – which will take six months – and then get an answer.

“We will know if a virus causes skin cancer and what virus it is,” he said.

 

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  1. #1 by Hein Vandenbergh on July 31, 2011 - 8:19 am

    There is certainly corroborative evidence in e.g. transplant patients and others who are immune suppressed – although there is also good evidence that active immunity against DNA damage induced by physical factors NOT of a viral nature exists; this would be equally compromised by a reduction in immune-competence. But full marks for trying!

    Who said that old age is merely the combined effect of gravity combined with viral take-over of cell DNA? All we need then is an anti-gravitron vaccine and there’s your elixir of life!

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