Nested melanoma

Hi there

Here is a  new article on this newly identified entity:

Dermoscopy and Confocal Microscopy of Nested Melanoma of the Elderly: Recognizing a Newly Defined Entity

Importance  Nested melanoma of the elderly is a newly identified histopathologic variant of superficial spreading melanoma, characterized by intraepidermal large nests. However, the clinical, dermoscopic, and confocal aspects have been depicted only partially.

Observations  In our cases series, nested melanoma was a flat, irregularly shaped lesion with variably pigmented and irregularly distributed globules on dermoscopic examination. Confocal microscopy revealed the presence of a “clod” pattern made of large compact nests with variable atypia. These findings correlated well with histopathologic features.

Conclusions and Relevance  Nested melanoma of the elderly should be included in the differential diagnosis when a flat pigmented lesion, showing dermoscopically an irregular globular pattern, is seen in a patient older than 60 years.

and the editorial comment:



  1. #1 by hein on June 11, 2013 - 4:06 am

    It’s an SSM – why the new nomenclature? Not al SSMs I’m sure have exactly the same distribution of abnormal melanocytes, yet we do not name them accordingly. They’re in the epidermis, it’s superficially spreading, and – by the sound of it – you need a confocal microscope [here, have three, I bought a cheap batch the other day when shopping at Zeiss] to diagnose it.

    NMOTE – yet another acronym to remember – or confuse others with.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: