Archive for June, 2012
Came across this the other day which may be useful to some
Description from website
The Dermatologic Cooperative Oncology Group (DECOG) developed the first free iPhone app for staging cutaneous melanoma patients according to the AJCC 2009 classification system. After entering data like tumor thickness, ulceration, mitotic rate, micro/macrometastases of lymph nodes as well as data for distant metastases the current TNM classification, clinical staging and average 5-year overall survival is calculated. Results can be transferred by e-mail on request.
Through a link to the DECOG homepage further information is provided (treatment guidelines, clinical trials registry).
This app is designed for physicians to simplify the classification of melanoma patients. Prognostic data is average and does not reflect the individual course of the patient. This app cannot substitute a consultation with your treating physician.
Have a look at this if you are interested in dermpath.
This was in journal watch. Does anyone use DMSO?
Long-term results show 5-aminolevulinic acid photodynamic therapy to be beneficial for basal cell carcinomas when surgery is not a good option.
Although surgical removal is the mainstay of basal cell carcinoma (BCC) therapy, additional options are desirable in some situations. One alternative is 5-aminolevulinic acid photodynamic therapy (ALA-PDT), but data are scarce concerning which BCC types are amenable to this treatment and long-term outcomes. In this study, investigators treated 60 BCCs in 44 patients with one or two sessions of ALA-PDT and followed them for 10 years. Morpheaform and pigmented BCCs were excluded from treatment, but recurrent lesions were included. The protocol involved debulking of the tumor, treatment with the drug penetration enhancer dimethylsulfoxide (DMSO) for 5 minutes, followed by ALA-PDT. ALA was activated by a broadband light unit with an emission spectrum in the 550–700 nm range.
The 10-year complete response rates were 87% with two treatment sessions and 60% with one session. All recurrences developed within 3 years of treatment. At 10 years, 90% of the primary tumors were recurrence free, but ALA-PDT was effective for only two of the five recurrent tumors. Recurrences were more likely in men. Physician evaluators considered the cosmetic outcome to be excellent or good in 90% of treated sites at 1 year and in 100% at 10 years.
Comment: Long-term results with 5-aminolevulinic acid photodynamic therapy for basal cell carcinomas are very positive — comparable to other nonsurgical interventions. Longer-wavelength light sources in the 625-nm range (as used in this study) are probably the best choice for BCC treatment, because they penetrate more deeply into the skin than shorter-wavelength blue lights. The authors speculate that DMSO may have contributed to efficacy by augmenting conversion of ALA to its active metabolite. Dermatologists may wish to consider ALA-PDT for primary BCCs when surgical procedures should be avoided.
Published in Journal Watch Dermatology June 15, 2012
Christensen E et al. High and sustained efficacy after two sessions of topical 5-aminolaevulinic acid photodynamic therapy for basal cell carcinoma: A prospective, clinical and histological 10-year follow-up study. Br J Dermatol 2012 Jun; 166:1342.
- Medline abstract (Free)
I have mentioned this before. I wonder if it would be useful in our regular patients who can have more than 10 BCC’s a year?
A NEWLY approved drug has shown promise in keeping two rare variations of skin cancer at bay, according to research published in the New England Journal of Medicine recently.
The drug, Erivedge (vismodegib), is made by Genentech, a US subsidiary of the Swiss drug giant Roche, and was approved by the US Food and Drug Administration in January after an expedited review.
It aims to treat basal cell carcinoma, which is the most common form of skin cancer in the world but which is rarely deadly. Basal cell carcinoma accounts for 80 per cent of nonmelanoma cancers and some two million new cases in the US each year.
The journal published two studies that show how it helped some patients with two unusual variations of basal cell carcinoma: metastatic basal cell carcinoma and Gorlin syndrome, also known as Basal Cell Nevus Syndrome.
There is no other treatment for Gorlin syndrome, which strikes one in 50,000 people and involves the constant growth of tumours, which are often not deadly but can cause scarring and require frequent surgeries. Subjects with Gorlin syndrome who took vismodegib developed an average of two new tumors per year, compared with 29 new tumors in subjects taking a placebo, the study said.
When it came to people whose basal cell carcinoma had spread, the study showed 30 per cent of 33 patients with metastatic basal cell carcinoma responded to treatment, meaning their tumors shrank. Forty-three per cent of 63 subjects with locally advanced basal cell carcinoma responded in kind.
The phase II study showed a median progression-free survival time of 9.5 months, but overall survival rates have not yet been established. “It is a landmark day for patients with basal cell carcinoma and all those involved in their care — the greatest advance in therapy yet seen for this disease,” said an accompanying editorial by John Lear, consultant dermatologist at Manchester Royal Infirmary in Britain.
However, he pointed out the high rate of adverse effects, including loss of taste, hair loss and muscle cramps, which led to a high rate of people dropping out of the study early.
“Side effects are considerable and frequent, resulting in high rates of drug discontinuation, and these rates will probably be even higher in clinical practice,” Lear said.
More study is needed to determine how long the drug may work to ward off cancer, what populations it may best serve, and when it should be optimally administered, he added.